Pathway enrichment in genome-wide analysis of longitudinal Alzheimer's disease biomarker endophenotypes.

ABSTRACT:

Introduction

The genetic pathways that influence longitudinal heterogeneous changes in Alzheimer's disease (AD) may provide insight into disease mechanisms and potential therapeutic targets.

Methods

Longitudinal endophenotypes from the Alzheimer's Disease Neuroimaging Initiative (ADNI) representing amyloid, tau, neurodegeneration (A/T/N), and cognition were selected. Genome-wide association analysis was performed using a linear mixed model (LMM) approach, followed by gene and pathway enrichment with significant and functionally relevant SNPs.

Results

A total of 33 and 19 statistically significant pathways were identified associating with the intercept and longitudinal trajectory, respectively. The longitudinal intercept pathways represent eight groups: immune, metabol

SUBMITTER: Rosewood TJ 

PROVIDER: S-EPMC11667536 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature