Frontoparietal network integrity supports cognitive function in pre-symptomatic frontotemporal dementia: Multimodal analysis of brain function, structure, and perfusion.

ABSTRACT:

Introduction

Genetic mutation carriers of frontotemporal dementia can remain cognitively well despite neurodegeneration. A better understanding of brain structural, perfusion, and functional patterns in the pre-symptomatic stage could inform accurate staging and potential mechanisms.

Methods

We included 207 pre-symptomatic genetic mutation carriers and 188 relatives without mutations. The gray matter volume, cerebral perfusion, and resting-state functional network maps were co-analyzed using linked independent component analysis (LICA). Multiple regression analysis was used to investigate the relationship of LICA components to genetic status and cognition.

Results

Pre-symptomatic mutation carriers showed an age-related decrease in the left frontoparietal network integ

SUBMITTER: Liu X 

PROVIDER: S-EPMC11667541 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature