APOE 𝜀4-related blood-brain barrier breakdown is associated with microstructural abnormalities.

ABSTRACT:

Introduction

Blood-brain barrier (BBB) dysfunction occurs in Alzheimer's disease (AD). Yet, the stage at which it appears along the AD time course and whether it contributes to neurodegeneration remain unclear.

Methods

Older adults (61 to 90 years) from cognitively normal (CN) to mildly cognitively impaired (CI), enriched for APOE 𝜀4 and amyloid positivity, underwent dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and diffusion MRI to measure BBB permeability and brain microstructure. Analysis of variance compared BBB permeability according to cognitive status, amyloid beta (Aβ), and APOE4. Linear regressions assessed associations of BBB permeability with brain microstructure and interactions with Aβ and APOE4.

Results

BBB permeability was elevated f

SUBMITTER: Reas ET 

PROVIDER: S-EPMC11667544 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature