Association of amyloid and cardiovascular risk with cognition: Findings from KBASE.

ABSTRACT:

Background

Limited research has explored the effect of cardiovascular risk and amyloid interplay on cognitive decline in East Asians.

Methods

Vascular burden was quantified using Framingham's General Cardiovascular Risk Score (FRS) in 526 Korean Brain Aging Study (KBASE) participants. Cognitive differences in groups stratified by FRS and amyloid positivity were assessed at baseline and longitudinally.

Results

Baseline analyses revealed that amyloid-negative (Aβ-) cognitively normal (CN) individuals with high FRS had lower cognition compared to Aβ- CN individuals with low FRS (p < 0.0001). Longitudinally, amyloid pathology predominantly drove cognitive decline, while FRS alone had negligible effects on cognition in CN and mild cognitive impairment (MCI) groups.

Conc

SUBMITTER: Chaudhuri S 

PROVIDER: S-EPMC11667546 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature