Effectiveness of electro-acupuncture for cognitive improvement on Alzheimer's disease quantified via PET imaging of sphingosine-1-phosphate receptor 1.

ABSTRACT:

Introduction

Electro-acupuncture (EA) has demonstrated potential in improving mild-to-moderate dementia in clinics, but the underlying scientific target remains unclear.

Methods

EA was administered to APP/PS1 Alzheimer's disease (AD) mice, with untreated AD, and wild type (WT) mice serving as controls. The efficacy of EA was assessed by the Morris water maze cognitive functional tests. Brain magnetic resonance imaging-positron emission tomography (PET) scans using [¹⁸F]TZ4877 targeting sphingosine-1-phosphate receptor 1 (S1PR1) and [¹⁸F]AV45 targeting amyloid beta fibrils were conducted. The correlation between regional brain PET quantifications and cognitive functions was analyzed.

Results

EA significantly improved cognitive and memory functions

SUBMITTER: Wang L 

PROVIDER: S-EPMC11667549 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature