Biomarkers of endothelial dysfunction and cognition: A two-step IPD meta-analysis.

ABSTRACT:

Introduction

This study assessed the association of plasma biomarkers of endothelial dysfunction with cognitive performance and decline.

Methods

Data from 9414 individuals from eight Dutch cohorts were included (Ø  age-range: 57-93 years). Plasma biomarkers of endothelial dysfunction (soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble E-selectin) were combined into a standardized composite score. Cognitive outcomes included executive function, processing speed, immediate and delayed memory, attention, and language. Linear regressions and linear mixed models were run in the individual cohorts and standardized coefficients were subsequently pooled using random-effects meta-analyses.

Results

A higher endothel

SUBMITTER: Beran M 

PROVIDER: S-EPMC11667552 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature