Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology.

ABSTRACT:

Introduction

Factors responsible for the deposition of pathological tau in the brain are incompletely understood. This study links macroscale tau deposition in the human brain to cerebrospinal fluid (CSF) flow dynamics using resting-state functional magnetic resonance imaging (rsfMRI).

Methods

Low-frequency (< 0.1 Hz) resting-state global brain activity is coupled with CSF flow and potentially reflects CSF dynamics-related clearance. We examined the correlation between rsfMRI measures of CSF inflow and global activity (gBOLD-CSF coupling) as a predictor, interacting with amyloid beta (Aβ), of tau and cortical thickness (dependent variables) across Alzheimer's Disease Neuroimaging Initiative (ADNI) participants from cognitively unimpaired through mild cognitive impairment (MC

SUBMITTER: Han F 

PROVIDER: S-EPMC11667553 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature