Real-world effectiveness and causal mediation study of BNT162b2 on long COVID risks in children and adolescents.

ABSTRACT:

Background

The impact of pre-infection vaccination on the risk of long COVID remains unclear in the pediatric population. We aim to assess the effectiveness of BNT162b2 on long COVID risks with various strains of the SARS-CoV-2 virus in children and adolescents, using comparative effectiveness methods. We further explore if such pre-infection vaccination can mitigate the risk of long COVID beyond its established protective benefits against SARS-CoV-2 infection using causal mediation analysis.

Methods

We conducted real-world vaccine effectiveness study and mediation analysis using data from twenty health systems in the RECOVER PCORnet electronic health record (EHR) Program. Three independent cohorts were constructed including adolescents (12-20 years) during the Delta phase (

SUBMITTER: Wu Q 

PROVIDER: S-EPMC11667630 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature