Amplified Light-Induced p<i>K</i>_a Modulation with Diarylethene Photoswitches.

ABSTRACT: The reversible modulation of acidity using molecular photoswitches enables the remote control of a variety of (bio)chemical processes with light. Herein we investigated the structural features that allow amplifying photoinduced pK_a variation in phenol-diarylethene conjugates, which toggle between low- and high-acidity states by switching the conjugation between the ionizable moiety and electron-withdrawing groups upon photoisomerization. By tuning the structure of these conjugates, high pK_a modulation amplitudes were accomplished that surpass those previously reported.

SUBMITTER: Villabona M 

PROVIDER: S-EPMC11667731 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature