Planned delivery or expectant management for late preterm pre-eclampsia in low-income and middle-income countries (CRADLE-4): a multicentre, open-label, randomised controlled trial.

ABSTRACT:

Background

Pre-eclampsia is a leading cause of maternal and perinatal mortality. Evidence regarding interventions in a low-income or middle-income setting is scarce. We aimed to evaluate whether planned delivery between 34^+ 0 and 36^+ 6 weeks' gestation can reduce maternal mortality and morbidity without increasing perinatal complications in India and Zambia.

Methods

In this parallel-group, multicentre, open-label, randomised controlled trial, we compared planned delivery versus expectant management in women with pre-eclampsia from 34^+ 0 to 36^+ 6 weeks' gestation. Participants were recruited from nine hospitals and referral facilities in India and Zambia and randomly assigned to planned delivery or expectant management in a 1:1 rati

SUBMITTER: Beardmore-Gray A 

PROVIDER: S-EPMC11667733 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature