Resting-State Functional Connectivity of the Amygdala in Autism: A Preregistered Large-Scale Study.

ABSTRACT:

Objective

Three leading neurobiological hypotheses about autism spectrum disorder (ASD) propose underconnectivity between brain regions, atypical function of the amygdala, and generally higher variability between individuals with ASD than between neurotypical individuals. Past work has often failed to generalize, because of small sample sizes, unquantified data quality, and analytic flexibility. This study addressed these limitations while testing the above three hypotheses, applied to amygdala functional connectivity.

Methods

In a comprehensive preregistered study, the three hypotheses were tested in a subset (N=488 after exclusions; N=212 with ASD) of the Autism Brain Imaging Data Exchange data sets. The authors analyzed resting-state functional connectivity (FC) from func

SUBMITTER: Kliemann D 

PROVIDER: S-EPMC11667795 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature