Tail Fin Regeneration in Zebrafish: The Role of Non-canonical Crosstalk Between STAT3 and Vitamin D Pathway.

ABSTRACT: Stat3 is a transcription factor with a key role in cell proliferation and migration. Using the stat3^-/- zebrafish line we showed that the stat3 genetic ablation results in a marked decrease of tail fin regrowth, demonstrating that this transcription factor is fundamental in the regeneration process. Stat3 activity is finely modulated by post-translational modifications that occur in several residues of the protein (i.e., Y705 and S727 phosphorylation), with tissue-specific effects. Using the newly generated stat3^S→A751 zebrafish line, we demonstrated that the Stat3 phosphorylation in the non-canonical S751 site (homologous of mammalian serine 727) is required for the regeneration of tail fin in both larval and adult stage, even if this phosphoryla

SUBMITTER: Tesoriere A 

PROVIDER: S-EPMC11667806 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature