Advanced Lung-on-a-Chip Technology: Mimicking the Complex Human Lung Microenvironment.

ABSTRACT: Intricate crosstalk among various lung cell types is crucial for orchestrating diverse physiological processes. Traditional two-dimensional and recent three-dimensional (3D) assay platforms fail to precisely replicate these complex communications. Many in vitro lung models do not effectively reflect the multicellular complexity of lung tissue. Here, we fabricated an advanced multicellular 3D lung-on-a-chip system that properly replicates the dynamic pulmonary microenvironment and its intricate microarchitecture. Diverse lung cells were incorporated into a microstructure formed from a mixture of natural polymers, including collagen and hyaluronic acid, and blood coagulation factors acting as natural crosslinking agents. The system accurately reflects the complex 3D architecture of th

SUBMITTER: Min EK 

PROVIDER: S-EPMC11667821 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature