Prostanoid signaling in retinal cells elicits inflammatory responses relevant to early-stage diabetic retinopathy.

ABSTRACT: Inflammation is a critical driver of the early stages of diabetic retinopathy (DR) and offers an opportunity for therapeutic intervention before irreversible damage and vision loss associated with later stages of DR ensue. Nonsteroidal anti-inflammatory drugs (NSAIDs) have shown mixed efficacy in slowing early DR progression, notably including severe adverse side effects likely due to their nonselective inhibition of all downstream signaling intermediates. In this study, we investigated the role of prostanoids, the downstream signaling lipids whose production is inhibited by NSAIDs, in promoting inflammation relevant to early-stage DR in two human retinal cell types: Müller glia and retinal microvascular endothelial cells. When cultured in multiple conditions modeling distinct aspects of s

SUBMITTER: Stark AK 

PROVIDER: S-EPMC11667846 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature