Fasting recovers age-related hypertension in the rats: reset of renal renin-angiotensin system components and klotho.

ABSTRACT:

Background

The renal renin-angiotensin system (RAS) plays a vital part in the control of blood pressure and is known to be affected by aging. This study aimed to investigate the effects of intermittent fasting on age-related hypertension and the expression of local renal RAS components.

Methods

The Wistar rats were categorized into three main age groups (young, middle aged, and elderly) and three dietary treatment models, including ad libitum feeding (AL), every other day fasting (EOD), and one day per week of fasting (FW). After three months, blood pressure (BP) was assessed. Some genes and proteins of the renal RAS system were measured by using Real time PCR and Western blot. α-klotho and Ang II proteins were assessed by ELISA method.

Results

Old rats exhibited sign

SUBMITTER: Badreh F 

PROVIDER: S-EPMC11667979 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature