Reprogramming tumor-associated macrophages with lipid nanosystems reduces PDAC tumor burden and liver metastasis.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma (PDAC) requires innovative therapeutic strategies to counteract its progression and metastatic potential. Since the majority of patients are diagnosed with advanced metastatic disease, treatment strategies targeting not only the primary tumor but also metastatic lesions are needed. Tumor-Associated Macrophages (TAMs) have emerged as central players, significantly influencing PDAC progression and metastasis. Our objective was to validate an innovative therapeutic strategy involving the reprogramming of TAMs using lipid nanosystems to prevent the formation of a pro-metastatic microenvironment in the liver.

Results

In vitro results demonstrate that M2-polarized macrophages lose their M2-phenotype following treatment with lipid nanoemu

SUBMITTER: Palencia-Campos A 

PROVIDER: S-EPMC11668009 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature