Regulatory T cell expansion prevents retinal degeneration in type 2 diabetes.

ABSTRACT:

Background

The global incidence of type 2 diabetes (T2D) is rapidly increasing, with retinopathy being its most common complication and a leading cause of preventable blindness. Although the precise mechanisms involved in the development of diabetic retinopathy (DR) are not fully understood, defective immunomodulation is a recognized key factor in its pathophysiology. Regulatory T cells (Treg) regulate inflammation and promote regeneration, and while they are known to have important anti-inflammatory and neuroprotective roles in other tissues, including central nervous system, their role in the diabetic retina remains largely unknown. The aim of the present study is to examine the effect of Treg expansion of retinal neurodegeneration, an early event in the pathogenesis of DR.

Me

SUBMITTER: Llorian-Salvador M 

PROVIDER: S-EPMC11668053 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature