Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for hyperemesis gravidarum.

ABSTRACT:

Background

Hyperemesis gravidarum (HG), excessive vomiting in pregnancy, occurs in 0.3-10.8% of pregnancies and is associated with maternal and fetal morbidity. Despite the existence of several off-label treatment options that have shown clinical effectiveness in managing HG symptoms, the variability in treatment response highlights the need for more effective therapies. Our study aims to identify novel therapeutic targets that could lead to the development of additional, more effective treatment options.

Methods

A two-sample Mendelian randomization (MR) analysis was performed to estimate the causal effects of blood-druggable genes on HG. Summary statistics for HG were obtained from the FinnGen study and UK Biobank. Cis-expression quantitative trait loci (cis-eQTL) for blood

SUBMITTER: Wang F 

PROVIDER: S-EPMC11668092 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature