Pooling Biospecimens for Efficient Exposure Assessment When Using Case-Cohort Analysis in Cohort Studies.

ABSTRACT:

Background

Large prospective cohort studies have been fruitful for identifying exposure-disease associations. In a cohort where biospecimens (e.g., blood, urine) were collected at enrollment, analysts can exploit a case-cohort approach: Biospecimens from a random sample of cohort participants, called the "subcohort," plus a sample of incident cases that were not part of the subcohort are assayed. Reusing subcohort data for multiple disease outcomes can reduce costs and conserve specimen archives. Pooling biospecimen samples before assay could both save money and reduce depletion of the archive but has not been studied for cohort studies.

Objectives

We develop and evaluate a biospecimen pooling strategy for case-cohort analyses that relate an exposure to risk of a rare diseas

SUBMITTER: Shi M 

PROVIDER: S-EPMC11668240 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature