Functional role of the biofilm regulator CsgD in <i>Salmonella enterica</i> sv. Typhi.

ABSTRACT:

Introduction

Typhoid fever is an infectious disease primarily caused by Salmonella enterica sv. Typhi (S. Typhi), a bacterium that causes as many as 20 million infections and 600,000 deaths annually. Asymptomatic chronic carriers of S. Typhi play a major role in the transmission of typhoid fever, as they intermittently shed the bacteria and can unknowingly infect humans in close proximity. An estimated 90% of chronic carriers have gallstones; biofilm formation on gallstones is a primary factor in the establishment and maintenance of gallbladder carriage. CsgD is a central biofilm regulator in Salmonella, but the S. Typhi csgD gene has a mutation that introduces an early stop codon, resulting in a protein truncated by 8 amino acids at the C-terminu

SUBMITTER: Gonzalez JF 

PROVIDER: S-EPMC11668344 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature