Peeking into the future: inferring mechanics in dynamical tissues.

ABSTRACT: Cells exert forces on each other and their environment, shaping the tissue. The resulting mechanical stresses can be determined experimentally or estimated computationally using stress inference methods. Over the years, mechanical stress inference has become a non-invasive, low-cost computational method for estimating the relative intercellular stresses and intracellular pressures of tissues. This mini-review introduces and compares the static and dynamic modalities of stress inference, considering their advantages and limitations. To date, most software has focused on static inference, which requires only a single microscopy image as input. Although applicable in quasi-equilibrium states, this approach neglects the influence that cell rearrangements might have on the inference. In contras

SUBMITTER: Borges A 

PROVIDER: S-EPMC11668348 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature