Intravital Imaging of Disease Mechanisms in a Mouse Model of CCM Skin Lesions-Brief Report.

ABSTRACT:

Background

Cerebral cavernous malformation (CCM) is a disease characterized by vascular malformations that primarily develop in the brain. These malformations are prone to leak, and their rupture or thrombotic closure can cause life-threatening hemorrhages and strokes. Mouse models have been instrumental to study the disease, but most cause premature lethality, precluding the investigation of disease mechanisms through intravital microscopy. Current mouse models also do not recapitulate human CCM skin lesions.

Methods

Endothelial-specific deletion of Ccm3 via systemic tamoxifen application at postnatal day 4 or 5 prolongs survival and induces vascular malformations in the mouse brain and ear skin. CCM skin lesions can also be induced by topical tamoxifen administratio

SUBMITTER: Orlich MM 

PROVIDER: S-EPMC11668616 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature