Proteomic analysis of the <i>Treponema pallidum</i> subsp. <i>pallidum</i> SS14 strain: coverage and comparison with the Nichols strain proteome.

ABSTRACT:

Introduction

Strains of the syphilis spirochete, Treponema pallidum ssp. pallidum, group into one of two deep-branching clades: the Nichols clade or the globally dominant Street Strain 14 (SS14) clade. To date, in-depth proteome-wide analyses have focused on Nichols clade strains.

Methods

The T. pallidum SS14 clade reference strain (SS14) proteome was characterized via protein detection and quantification analyses using mass spectrometry, and comparison was made to the Nichols clade reference strain (Nichols) proteome.

Results

Approximately two thirds of all proteins from T. pallidum SS14 were detected and quantitated, allowing confirmation of expression of 259 proteins for the first time in this strain, including 11 known/putative outer me

SUBMITTER: Houston S 

PROVIDER: S-EPMC11668736 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature