An atlas of the shared genetic architecture between atopic and gastrointestinal diseases.

ABSTRACT: Comorbidity among atopic diseases (ADs) and gastrointestinal diseases (GIDs) has been repeatedly demonstrated by epidemiological studies, whereas the shared genetic liability remains largely unknown. Here we establish an atlas of the shared genetic architecture between 10 ADs or related traits and 11 GIDs, comprehensively investigating the comorbidity-associated genomic regions, cell types, genes and genetically predicted causality. Although distinct genetic correlations between AD-GID are observed, including 14 genome-wide and 28 regional correlations, genetic factors of Crohn's disease (CD), ulcerative colitis (UC), celiac disease and asthma subtypes are converged on CD4⁺ T cells consistently across relevant tissues. Fourteen genes are associated with comorbidities, with three

SUBMITTER: Qi C 

PROVIDER: S-EPMC11668890 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature