Peptide Cy _RL-QN15 accelerates hair regeneration in diabetic mice by binding to the Frizzled-7 receptor.

ABSTRACT: Individuals with diabetes frequently face serious challenges, including delayed wound healing and increased risk of infection. Notably, the regeneration of hair follicles plays a crucial role in accelerating diabetic skin damage repair, reducing the risk of infection, and enhancing overall skin health. Research has predominantly emphasized the re-epithelialization of diabetic wounds, with a paucity of in-depth studies on hair follicle regeneration. In the current study, we explored the effects of a bioactive amphibian-derived peptide, Cy _RL-QN15, on promoting hair regeneration in a diabetic skin model. In vivo experiments demonstrated that local treatment with Cy _RL-QN15 not only accelerated wound healing of scalded skin on the backs of diabetic Kunming (KM) mi

SUBMITTER: Wu YT 

PROVIDER: S-EPMC11668943 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature