Metabolic Features of Assigned Female at Birth Transgender People on Gender-Affirming Hormone Therapy: A Meta-analysis.

ABSTRACT:

Purpose

There is a paucity of data on the safety and efficacy of long-term testosterone (T)-based gender-affirming hormone therapy (GAHT) on anthropometric parameters, body composition, and glycolipid metabolism in assigned female at birth (AFAB) persons. The purpose of this study was to provide an updated meta-analysis on this topic.

Methods

We searched PubMed, Scopus, and Cochrane Library for relevant studies. Pre-/post-therapy changes in body mass index (BMI), waist-to-hip ratio (WHR), body composition, lipid glycemic/insulinemic profiles were combined as mean differences (MD) with 95% confidence interval (CI), using random-effect models.

Results

Thirty-nine studies (N=1949) were analyzed. At pooled estimates, GAHT was associated with significant decrease in

SUBMITTER: Tienforti D 

PROVIDER: S-EPMC11669637 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature