Early developmental changes in GABAA receptor expression in nucleus accumbens medium spiny neurons.

ABSTRACT: The expression of GABA_ARs goes through large scale, evolutionarily conserved changes through the early postnatal period. While these changes have been well-studied in brain regions such as the hippocampus and sensory cortices, less is known about early developmental changes in other brain areas. The nucleus accumbens (NAc) is a major hub in the circuitry that mediates motivated behaviors and disruptions in NAc activity is a part of the neuropathology observed in mood and substance use disorders. Considering the importance of early developmental disruptions in the vulnerability to and etiology of these disorders, it is essential to understand normal developmental changes in the NAc as a first step to understanding how these changes might be disrupted to cause long-term pathology.

SUBMITTER: Wang ZZ 

PROVIDER: S-EPMC11669658 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature