The relationship between inflammatory factors and heart failure: evidence based on bidirectional Mendelian randomization analysis.

ABSTRACT:

Objective

Inflammatory factors play a crucial role in the onset and progression of heart failure. To further explore the causal relationship between inflammatory factors and heart failure, we employed bidirectional Mendelian randomization analysis to investigate the causal links between 91 inflammatory cytokines and heart failure.

Methods

We conducted our study using the bidirectional Mendelian randomization approach. Data on 91 inflammatory factors were sourced from large-scale public genome-wide association study databases, while heart failure data were obtained from the FINNGEN database. The relationships between inflammatory factors and heart failure were evaluated using five methods: MR-Egger regression model, Inverse Variance Weighted method, Simple mode model, Weighte

SUBMITTER: Huang X 

PROVIDER: S-EPMC11669679 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature