Macranthoidin B restrains the epithelial-mesenchymal transition through COX-2/PGE₂ pathway in endometriosis.

ABSTRACT:

Introduction

Macranthoidin B is one of the primary and unique triterpenoid saponin metabolites from Lonicera macranthoides Hand. -Mazz, which is used to treat endometriosis (EMS) in traditional Chinese medicine. However, the effect of macranthoidin B remains unknown in EMS. This study aimed to elucidate the effect and mechanism of macranthoidin B in EMS.

Methods

Using rat autograft EMS model, the volume of ectopic endothelium, the histopathology, serum E₂ and PROG were evaluated after macranthoidin B's treatment. In primary endometriotic stromal and HEC1-B cells, the invasion and metastasis were assessed by scratch wound and Transwell tests. The epithelial-mesenchymal transition and COX-2/PGE₂ pathway were examined in vivo and in vitro<

SUBMITTER: Ding Y 

PROVIDER: S-EPMC11669684 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature