The causal relationship between 233 metabolites and coronary atherosclerosis: a Mendelian randomization study.

ABSTRACT:

Objective

To investigate the causal relationship between 233 newly reported metabolites and coronary atherosclerosis through Mendelian randomization analysis.

Methods

Five different methods were used to perform Mendelian randomization analysis on the 233 metabolites and coronary atherosclerosis, with inverse variance weighting as the primary result, supplemented by other methods.

Results

The analysis identified that certain metabolites increase the susceptibility risk of coronary atherosclerosis, including: Total fatty acids (OR = 1.40, 95% CI: 1.28-1.53, P < 0.001), Saturated fatty acids (OR = 1.44, 95% CI: 1.30-1.60, P < 0.001), Serum total triglyceride levels (OR = 1.33, 95% CI: 1.22-1.46, P < 0.001), Conjugated linoleic acid (OR = 1.16, 95% CI

SUBMITTER: Zhang H 

PROVIDER: S-EPMC11669696 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature