Serum glycobiomarkers for chronic inflammatory demyelinating polyneuropathy.

ABSTRACT:

Background

This study conducted a comprehensive glycan analysis of serum to determine how glycan biomarkers are associated with the pathophysiology of chronic inflammatory demyelinating polyneuropathy (CIDP) and the effects of its treatment.

Methods

We comparatively analyzed N- and O-glycans in the pretreatment serum of 27 treatment-naïve patients with typical CIDP and 20 age- and sex-matched healthy controls (HC) using mass spectrometry. We determined the association between clinical parameters and glycans. The serum glycan and neurofilament light-chain (NfL) levels were assessed at the baseline, and treatment response was defined according to the degree of improvement in the modified Rankin scale 12 weeks after the first dose of intravenous immunoglobulin (IVIg).

Result

SUBMITTER: Furukawa S 

PROVIDER: S-EPMC11669748 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature