Effect of autoimmune comorbidities on multiple sclerosis course: An observational multicenter study.

ABSTRACT:

Background

The study aims to examine the age and disability levels at diagnosis in people with multiple sclerosis (PwMS), with and without autoimmune comorbidities (AC), and the effect of AC on NEDA-3 status and to characterize AC associated with MS, comparing also therapeutic approaches between MS patients with and without other AC.

Methods

This population-based, multicentric study enrolled patients with relapsing-remitting MS (RRMS) with AC (AC group) or without AC (reference group) from 14 MS centers. Demographical, clinical features, treatment information, MRI activity, EDSS, and no evidence of disease activity (NEDA-3) status were assessed at T36 (enrollment time) and T0 (36 months prior).

Results

Eight hundred seventy-three RRMS patients were included; 215 (24.7

SUBMITTER: Nociti V 

PROVIDER: S-EPMC11669769 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature