Accelerated cell-type-specific regulatory evolution of the human brain.

ABSTRACT: The molecular basis of human brain evolution is a key piece in understanding the evolution of human-specific cognitive and behavioral traits. Comparative studies have suggested that human brain evolution was accompanied by accelerated changes of gene expression (referred to as "regulatory evolution"), especially those leading to an increase of gene products involved in energy production and metabolism. However, the signals of accelerated regulatory evolution were not always consistent across studies. One confounding factor is the diversity of distinctive cell types in the human brain. Here, we leveraged single-cell human and nonhuman primate transcriptomic data to investigate regulatory evolution at cell-type resolution. We relied on six well-established major cell types: excitatory and in

SUBMITTER: Joshy D 

PROVIDER: S-EPMC11670112 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature