Mechanism of proton release during water oxidation in Photosystem II.

ABSTRACT: Photosystem II (PSII) catalyzes light-driven water oxidation that releases dioxygen into our atmosphere and provides the electrons needed for the synthesis of biomass. The catalysis occurs in the oxygen-evolving oxo-manganese-calcium (Mn₄O₅Ca) cluster that drives the oxidation and deprotonation of substrate water molecules leading to the O₂ formation. However, despite recent advances, the mechanism of these reactions remains unclear and much debated. Here, we show that the light-driven Tyr161_D1 (Y_z) oxidation adjacent to the Mn₄O₅Ca cluster, decreases the barrier for proton transfer from the putative substrate water molecule (W3/W_x) to Glu310_D2, accessible to the luminal bulk. By combining hy

SUBMITTER: Allgower F 

PROVIDER: S-EPMC11670119 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature