Metagenomic Analysis Identifies Sex-Related Gut Microbial Functions and Bacterial Taxa Associated With Skeletal Muscle Mass.

ABSTRACT:

Background

This study aimed to explore the association between gut microbiota functional profiles and skeletal muscle mass, focusing on sex-specific differences in a population under 65 years of age.

Methods

Stool samples from participants were analysed using metagenomic shotgun sequencing. Skeletal muscle mass and skeletal muscle mass index (SMI) were quantified (SMI [%] = total appendage muscle mass [kg]/body weight [kg] × 100) using bioelectrical impedance analysis. Participants were categorized into SMI quartiles, and associations between gut microbiota, functional profiling and SMI were assessed by sex, adjusting for age, BMI and physical activity.

Results

The cohort included 1027 participants (651 men, 376 women). In men, Escherichia coli (log2 fold change 3.08,

SUBMITTER: Park HA 

PROVIDER: S-EPMC11670178 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature