Complement C3d enables cell-mediated immunity capable of distinguishing spontaneously transformed from nontransformed cells.

ABSTRACT: Immune surveillance depends in part on the recognition of peptide variants by T cell antigen receptors. Given that both normal B cells and malignant B cells accumulate mutations we chose a murine model of multiple myeloma to test conditions to induce cell-mediated immunity targeting malignant plasma cell (PC) clones but sparing of normal PCs. Revealing a previously unknown function for intracellular C3d, we found that C3d engaged T cell responses against malignant PC in the bone marrow of mice that had developed multiple myeloma spontaneously. Our results show that C3d internalized by cells augments immune surveillance by several mechanisms. In one, C3d induces a master transcription regulator, E2f1, to increase the expression of long noncoding (lnc) RNAs, to generate peptides for MHC-I pr

SUBMITTER: Platt JL 

PROVIDER: S-EPMC11670236 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature