Docetaxel response in BRCA1,p53-deficient mammary tumor cells is affected by Huntingtin and BAP1.

ABSTRACT: Taxanes are frequently used anticancer drugs known to kill tumor cells by inducing mitotic aberrations and segregation defects. A defining feature of specific cancers, notably triple-negative breast cancer (TNBC) and particularly those deficient in BRCA1, is chromosomal instability (CIN). Here, we focused on understanding the mechanisms of docetaxel-induced cytotoxicity, especially in the context of BRCA1-deficient TNBC. Using functional genetic screens in CIN+ cells, we identified genes that mediate docetaxel response and found an interaction between Huntingtin (HTT) and BRCA1-associated protein-1 (BAP1). We employed Brca1^-/-;p53^-/- mammary tumor cells, derived from genetically engineered mouse tumors that closely mimic the human disease, to

SUBMITTER: Gonzalez-Fernandez M 

PROVIDER: S-EPMC11670238 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature