Fumagillin Shortage: How to Treat <i>Enterocytozoon bieneusi</i> Microsporidiosis in Solid Organ Transplant Recipients in 2024?

ABSTRACT: Intestinal microsporidiosis caused by Enterocytozoon bieneusi is an opportunistic infection that especially affects solid organ transplant (SOT) recipients. Management revolves around tapering the immunosuppressive regimen and/or using a specific anti-microsporidia treatment, but only fumagillin has demonstrated efficacy for treatment of this infection. Since fumagillin has been commercially discontinued, nitazoxanide is increasingly being used in this indication. We aimed to describe therapeutic management of E. bieneusi infections in this context. We conducted a French nationwide observational retrospective study on reported cases of E. bieneusi infections in SOT recipients. We identified 154 cases: 64 (41.6%) were managed by simply modifying the immunosuppressive re

SUBMITTER: Garrouste C 

PROVIDER: S-EPMC11670256 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature