Pilot study characterizing a single pooled preparation of equine platelet lysate for nebulization in the horse.

ABSTRACT:

Introduction

Platelet lysate (PL) demonstrates antimicrobial and anti-inflammatory properties offering potential for treatment of bacterial pneumonia in horses. It remains unknown whether nebulization is suitable for PL administration in horses. This pilot study characterized particle size and flow rate of pooled equine PL (single preparation) nebulized using an equine-specific nebulizer (Flexivent^®).

Methods

Protein composition and antimicrobial activity were compared before and after nebulization. Protein composition was evaluated according to growth factor, antimicrobial peptide and cytokine concentrations and proteomic analysis. To evaluate antimicrobial activity, bacterial growth inhibition [maximum growth (μmax); carrying capacity (K)] were determined for

SUBMITTER: Egli P 

PROVIDER: S-EPMC11670369 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature