Unveiling the molecular blueprint of SKP-SCs-mediated tissue engineering-enhanced neuroregeneration.

ABSTRACT: Peripheral nerve injury poses a significant challenge to the nervous system's regenerative capacity. We previously described a novel approach to construct a chitosan/silk fibroin nerve graft with skin-derived precursor-induced Schwann cells (SKP-SCs). This graft has been shown to promote sciatic nerve regeneration and functional restoration to a level comparable to that achieved by autologous nerve grafts, as evidenced by behavioral, histological, and electrophysiological assessments. However, the underlying molecular mechanisms based on SKP-SCs mediated tissue engineering-aid regeneration remain elusive. In the present work, we systematically identified gene modules associated with the differentiation of SKPs into SCs by employing weighted gene co-expression network analysis (WGCNA). By i

SUBMITTER: Zhu H 

PROVIDER: S-EPMC11670488 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature