Exploring the molecular mechanism of estrogen therapy effectiveness after TCRA in IUA patients at single-cell level.

ABSTRACT:

Background

Intrauterine adhesion (IUA) is a common cause of clinically refractory infertility, and there exists significant heterogeneity in the treatment outcomes among IUA patients with the similar severity after transcervical resection of adhesion(TCRA). The underlying mechanism of different treatment outcomes occur remains elusive, and the precise contribution of various cell subtypes in this process remains uncertain.

Results

Here, we performed single-cell transcriptome sequencing on 10 human endometrial samples to establish a single-cell atlas differences between patients who responded to estrogen therapy and those who did not. The results showed increased infiltration of immune cells such as monocyte macrophages, T cells, and natural killer (NK) cells in patients who

SUBMITTER: Du Y 

PROVIDER: S-EPMC11670502 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature