Cannabichromene from full-spectrum hemp extract exerts acute anti-seizure effects through allosteric activation of GABA_A receptors.

ABSTRACT: The approval of Epidiolex, an anti-epileptic drug containing cannabidiol (CBD) as its active component, has brought hope to patients with refractory epilepsy. However, the anti-seizure effect of full-spectrum hemp extract (HE), a CBD-enriched hemp oil, remains unclear. In this study, we investigated the anti-seizure effect of HE using drug-induced seizure models. Our findings revealed that HE significantly reduced seizure susceptibility comparable to CBD at the same doses. Moreover, we explored the pharmacokinetic properties of CBD in HE and observed improved characteristics such as faster oral absorption, enhanced brain distribution, and slower elimination. We further assessed the anti-seizure effects of the other five main non-addictive components in HE. Among these components, cannabich

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11670702 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature