HER2-low expression in patients with advanced or metastatic solid tumors.

ABSTRACT:

Background

Human epidermal growth factor receptor 2 (HER2)-low is a newly defined category with HER2 1+ or 2+ expression by immunohistochemistry (IHC) and lack of HER2 gene amplification measured by in situ hybridization (ISH). Much remains unknown about the HER2-low status across tumor types and changes in HER2 status between primary and metastatic samples.

Patients and methods

HER2 expression by IHC was evaluated in 4701 patients with solid tumors. We have evaluated the HER2 expression by IHC and amplification by ISH in paired breast and gastric/gastroesophageal (GEJ) primary and metastatic samples. HER2 expression was correlated with ERBB2 genomic alterations evaluated by next-generation sequencing (NGS) in non-breast, non-gastric/GEJ samples.

Results

HER2 expressi

SUBMITTER: Uzunparmak B 

PROVIDER: S-EPMC11670753 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature