The impact of hydroxybutyl chitosan and 5-fluorouracil on the procedure of endoscopic endonasal dacryocystorhinostomy.

ABSTRACT:

Purpose

To investigate the effects of hydroxybutyl chitosan (HBCS) with and without 5-fluorouracil (5-FU) during endoscopic endonasal dacryocystorhinostomy (Endo-DCR). In addition, the present study observed the impact of HBCS and 5-FU on the functions of the nasal mucosal cell population in vivo .

Methods

Patients were randomized into HBCS (group A), HBCS combined with 5-FU (group B), and gelatin sponge control group (group C). 16S rRNA high-throughput sequencing technology examined the conjunctival sac and nasal flora changes. In addition, CCK8, cell scratching, and flow cytometry were used to investigate the effects of HBCS and 5-FU on the nasal mucosal cell populations.

Results

Subjects in groups A, B, and C had anastomotic areas of 21.83 ± 12.69 mm 2 , 21.57 ± 14

SUBMITTER: Lin JQ 

PROVIDER: S-EPMC11670833 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature