HLA EPLET Frequencies Are Similar in Six Population Groups and Are Expressed by the Most Common HLA Alleles.

ABSTRACT: The degree of immunological compatibility between donors and recipients greatly impacts allograft survival. In the United States kidney allocation system, HLA antigen-level matching has been shown to cause ethnic disparities and thus, has been de-emphasised. However, priority points are still awarded for antigen-level zero-ABDR matching, zero-DR matching and one-DR matching. Recently, the degree of HLA molecular (eplet) mismatch has emerged as a more accurate measure of immunological risk, and eplet mismatch load has gained attention as a possible biomarker to improve HLA compatibility. However, little is known about the frequency of eplets in population groups, which is a necessary step to ensure that candidates from any ethnical background can have similar chances at a well-matched organ

SUBMITTER: Mangiola M 

PROVIDER: S-EPMC11670879 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature