Uncovering population contributions to the extracellular potential in the mouse visual system using Laminar Population Analysis.

ABSTRACT: The local field potential (LFP), the low-frequency part of the extracellular potential, reflects transmembrane currents in the vicinity of the recording electrode. Thought mainly to stem from currents caused by synaptic input, it provides information about neural activity complementary to that of spikes, the output of neurons. However, the many neural sources contributing to the LFP, and likewise the derived current source density (CSD), can often make it challenging to interpret. Efforts to improve its interpretability have included the application of statistical decomposition tools like principal component analysis (PCA) and independent component analysis (ICA) to disentangle the contributions from different neural sources. However, their underlying assumptions of, respectively, orthogon

SUBMITTER: Rimehaug AE 

PROVIDER: S-EPMC11670981 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature