The Reproducibility and Reliability of Insulin Sensitivity and Secretion Indices in Children and Adolescents.

ABSTRACT:

Context

Insulin sensitivity and secretion indices can be useful tools in understanding insulin homeostasis in children at risk for diabetes. There have been few studies examining the reproducibility of these measures in pediatrics.

Objective

To determine whether fasting or oral glucose tolerance test (OGTT)-derived insulin measures would be more reproducible and whether there would be differences based on weight, sex, race, and pubertal status.

Design

Observational study.

Setting

Clinical research unit.

Patients or other participants

Two hundred fifty-seven overweight/obese (BMI ≥ 85th%, n = 186) and normal weight (BMI < 85th%, n = 71) children without diabetes between ages of 8 and 17 were included in the study.

Methods

OGTT tests p

SUBMITTER: Hani NS 

PROVIDER: S-EPMC11671114 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature