Dysfunctional copper homeostasis in <i>Caenorhabditis elegans</i> affects genomic and neuronal stability.

ABSTRACT: While copper (Cu) is an essential trace element for biological systems due to its redox properties, excess levels may lead to adverse effects partly due to overproduction of reactive species. Thus, a tightly regulated Cu homeostasis is crucial for health. Cu dyshomeostasis and elevated labile Cu levels are associated with oxidative stress and neurodegenerative disorders, but the underlying mechanisms have yet to be fully characterized. Here, we used Caenorhabditis elegans loss-of-function mutants of the Cu chaperone ortholog atox-1 and the Cu binding protein ortholog ceruloplasmin to model Cu dyshomeostasis, as they display a shifted ratio of total Cu towards labile Cu. We applied highly selective and sensitive techniques to quantify metabolites associated to oxidative stress with f

SUBMITTER: Weishaupt AK 

PROVIDER: S-EPMC11671132 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature