Probing the salivary proteome for prognostic biomarkers in response to non-surgical periodontal therapy.

ABSTRACT:

Aim

This prospective study investigated the salivary proteome before and after periodontal therapy.

Materials and methods

Ten systemically healthy, non-smoking, stage III, grade C periodontitis patients underwent non-surgical periodontal treatment. Full-mouth periodontal parameters were measured, and saliva (n = 30) collected pre- (T0), and one (T1) and six (T6) months post-treatment. The proteome was investigated by label-free quantitative proteomics. Protein expression changes were modelled over time, with significant protein regulation considered at false discovery rate <0.05.

Results

Treatment significantly reduced bleeding scores, percentages of sites with pocket depth ≥5 mm, plaque and gingival indexes. One thousand seven hundred and thirteen proteins were ident

SUBMITTER: Silbereisen A 

PROVIDER: S-EPMC11671166 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature