Gingival Crevicular Fluid Biomarkers During Periodontitis Progression and After Periodontal Treatment.

ABSTRACT:

Objective

To identify gingival crevicular fluid (GCF)-derived inflammatory markers of periodontitis progression and periodontal treatment impact.

Methods

Periodontally healthy (H; n = 112) and periodontitis (P; n = 302) patients were monitored bi-monthly for 1 year without therapy. Periodontitis patients were re-examined 6 months after non-surgical periodontal therapy (NSPT). Levels of 64 biomarkers were measured in the GCF samples collected at each visit from progressing (n = 12 sites in H; n = 76 in P) and stable (n = 100 in H, n = 225 in P) sites. Clinical parameters and log-transformed analyte levels were averaged within clinical groups at each time point and analysed using linear mixed models.

Results

During monitoring, progressing sites had significantly higher

SUBMITTER: Teles F 

PROVIDER: S-EPMC11671168 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature